Write my Paper on Drug Dosing
Write my Paper on Drug Dosing
Systemic Clearance Extended Calculation
A pharmaceutical company is developing a new drug ‘FCP-17’ and has just determined the following pharmacokinetic parameters from a Phase I human study:
Fraction unbound (fu): 0.5
Clearance by active secretion (CLsec): 5.4L/hr
Fraction reabsorbed (FR): 0.2
Hepatic Extraction Ratio (EH): 0.1
Question:
Showing all working out, and stating all assumptions, Calculate the total SYSTEMIC CLEARANCE for ‘FCP-17’.
2)- Inter-Individual Variability
A pharmaceutical company has convinced your paramedic service to add their new orally administered opioid analgesic ‘fucpoaphine’ to their formulary. Fucpoaphine requires hepatic activation in order to elicit an analgesic effect. Studies in healthy volunteers have demonstrated that fucpoaphine is rapidly activated (within 2minutes) following oral administration and that the sole enzyme involved in the activation of fucpoaphine is CYP2C19.
Questions:
a) Select ONE specific factor (environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of fucpoaphine, and explain the potential consequences of this variability in terms of treatment response and tolerability. (200 words)
B)-Identify a strategy to account for variability in fucpoaphine activation that can be used in a pre-hospital situation and briefly explain how this strategy could be used to optimise treatment response and tolerability. (100 words)
Need help with this Essay/Dissertation?
Get in touch Essay & Dissertation Writing services
Is this question part of your assignment?
Write my Paper on Drug Dosing
Write my Paper on Drug Dosing
Do you need help with your school ? At the Global Writers Network we offer many services that was designed effectively to meet your academic needs. We can write your papers, do your power points, help you with labs and final exams too. The work we provide is guaranteed to be 100% original and plagiarism free, here is the list of services we offer:
Write my Paper on Drug Dosing
Is the cost of the Custom & original writing too much for you? No worries. We offer a high quality tutorials. Through our tutorials store, you can by a sample solution for your assignment and download it instantly. Our tutorials are affordable and cost only $9.99 per tutorial. Go to www.gwrnt.com to purchase your tutorial or simply click on the the add below.
Write my Paper on Drug Dosing
Do you need help with this assignment ?
Watch the below videos to
Learn how we can help you.
The Global writers Network mission
News coverage on the Global Writers Network
Write my Paper on Drug Dosing
Systemic Clearance Extended Calculation
A pharmaceutical company is developing a new drug ‘FCP-17’ and has just determined the following pharmacokinetic parameters from a Phase I human study:
Fraction unbound (fu): 0.5
Clearance by active secretion (CLsec): 5.4L/hr
Fraction reabsorbed (FR): 0.2
Hepatic Extraction Ratio (EH): 0.1
Question:
Showing all working out, and stating all assumptions, Calculate the total SYSTEMIC CLEARANCE for ‘FCP-17’.
2)- Inter-Individual Variability
A pharmaceutical company has convinced your paramedic service to add their new orally administered opioid analgesic ‘fucpoaphine’ to their formulary. Fucpoaphine requires hepatic activation in order to elicit an analgesic effect. Studies in healthy volunteers have demonstrated that fucpoaphine is rapidly activated (within 2minutes) following oral administration and that the sole enzyme involved in the activation of fucpoaphine is CYP2C19.
Questions:
a) Select ONE specific factor (environmental, genetic or physiological) that may contribute to inter-individual variability in the activation of fucpoaphine, and explain the potential consequences of this variability in terms of treatment response and tolerability. (200 words)
B)-Identify a strategy to account for variability in fucpoaphine activation that can be used in a pre-hospital situation and briefly explain how this strategy could be used to optimise treatment response and tolerability. (100 words)
Need help with this Essay/Dissertation?
Get in touch Essay & Dissertation Writing services
Is this question part of your assignment?
Write my Paper on Drug Dosing